The Biotoxin Pathway Shoemaker The Biotoxin Pathway In genetically susceptible people, Body acquires biotoxins Biotoxin - HLA not susceptible Removal from the body In most people Biotoxin (HLA Susceptible) - go across the graph Biotoxin (HLA Susceptible) - go down the graph Nerve cell/axon Biotoxins have direct effects Sleep Disturbance Production of melatonin Chronic Pain Endorphin production Gastrointestinal Problems Lack of MSH Prolonged Illness White blood cellls Changes in Cortisol The pituitary may produce elevated Surface receptors dendritic cells increased leptin increased cytokines - down Excessive cytokine levels Leptin receptor Hypothalamus VIP MSH AVP Reduced MSH These arrows indicate Increased cytokines - across Capillaries High cytokine levels Immune System Symptoms Patients with certain HLA Fat cells then Split Products of c4a capillary Damaged leptin receptors Inflammation-related High levels of cytokines produce MMP-9 delivers inflammatory Resistant Coag-Negative Colonies of CARCoNS Reduced ADH Reduced MSH1 Reduced Androgens Reduced MSH2

       return to instructions on the graphic

'Mouse-overs'  of specific areas presently provide some additional explanation for the very complex process represented by the BioToxin Pathway graphic.  For each of these areas,  additional explanation  (via mouse-click)  provides an overlaid window offering: Note: Most of the extended information,  explanation,  and definitions described immediately above were taken from Wikipedia,  and from the writings of Dr. Ritchie C. Shoemaker,  author of the above Biotoxin Pathway graphic.